Publications

Browse InnoMol publications here

PUBLICATION	TYPE
Bis-phenanthridinium–adenine conjugates as fluorescent and CD reporters for fine structural differences in ds-DNA/RNA and ss-RNA structures Author or contact: Lidija-Marija Tumir, Filip Šupljika & Ivo Piantanida Journal: Supramolecular Chemistry Publisher: Taylor & Francis Year: 2016 Description: Two structurally similar bis-phenanthridinium–adenine conjugates (equipped with one or two adenines, respectively), exhibiting strong ds-DNA/RNA groove binding, revealed ratiometric uorescent recognition of alternating AT-DNA with respect to other ds-DNA/RNA and ss-RNA. Further, CD spectra pattern of adenine–bis-phenanthridinium conjugate/polynucleotide complexes strongly depended on polynucleotide secondary structure. Attached adenine was essential for spectrophotometric recognition response, ds-DNA stabilisation and orientation of compounds regarding chiral DNA helix.	SCI PUBLICATION
Death by UVC Light Correlates with Protein Damage in Isogenic Human Tumor Cells: Primary Tumor SW480 versus its Metastasis SW620 Author or contact: Andrea Nikolić, Matea Perić, Romain Ladouce, Ana-Matea Mikecin, Fernando A. Martin, Marijeta Kralj, Anita Kriško and Miroslav Radman Journal: vens Publishing Group Inviting Innovations Proteomics & Computational Biology Publisher: Avens Publishing Group Year: 2016 Description: A correlation between protein damage and death, but not DNA damage, was found among cells from robust and standard bacterial and invertebrate species. However, the bottleneck in DNA repair ef cacy appears more at the level of proteome damage than DNA damage. Here we present a comparative study of SW480 cells derived from a primary colon adenocarcinoma and SW620 metastatic cells derived from the same primary tumor and provide evidence that correlation between death and proteome damage extends to human tumor cells. A higher resistance of SW620 cells, compared to SW480, to killing by UVC light correlates with reduced levels of incurred irreversible oxidative protein damage (carbonylation) related to lower levels of ROS and of proteins intrinsically susceptible to oxidative damage due to imperfect folding. This study provides a concept for sensitizing tumor cells to cancer therapies and assessment of cancer cell tness.	SCI PUBLICATION
Functional and Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula Author or contact: Dragutin Perina, Marina Korolija, Marijana Popović Hadžija, Ivana Grbeša, Robert Belužić, Mirna Imešek, Christine Morrow, Melanija Posavec Marjanović, Tatjana Bakran-Petricioli, Andreja Mikoč and Helena Ćetković Journal: marine drugs Year: 2015 Description: Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (FAU) gene is down-regulated in human prostate, breast and ovarian cancers. Moreover, its dysregulation is associated with poor prognosis in breast cancer. Sponges (Porifera) are animals without tissues which branched off first from the common ancestor of all metazoans. A large majority of genes implicated in human cancers have their homologues in the sponge genome. Our study suggests that FAU gene from the sponge Suberites domuncula reflects characteristics of the FAU gene from the metazoan ancestor, which have changed only slightly during the course of animal evolution. We found pro-apoptotic activity of sponge FAU protein. The same as its human homologue, sponge FAU increases apoptosis in human HEK293T cells. This indicates that the biological functions of FAU, usually associated with “higher” metazoans, particularly in cancer etiology, possess a biochemical background established early in metazoan evolution. The ancestor of all animals possibly possessed FAU protein with the structure and function similar to evolutionarily more recent versions of the protein, even before the appearance of true tissues and the origin of tumors and metastasis. It provides an opportunity to use pre-bilaterian animals as a simpler model for studying complex interactions in human cancerogenesis.	SCI PUBLICATION
Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo Author or contact: Sandra Sobočanec, Vedrana Filić, Mihaela Matovina, Dragomira Majhen, Željka Malak Šafranko, Marijana Popović Hadžija, Željka Krsnik, Andrea Gutan Kurilj, Ana Šarić, Marija Abramić, Tihomir Balog Journal: Elsevier Publisher: Redox Biology Year: 2016 Description: A number of age-related diseases have a low incidence in females, which is attributed to a protective effect of sex hormones. For instance, the female sex hormone estrogen (E2) has a well established cy- toprotective effect against oxidative stress, which strongly contributes to ageing. However, the me- chanism by which E2 exerts its protective activity remains elusive. In this study we address the question whether the E2-induced protective effect against hyperoxia is mediated by the Nrf-2/Keap-1 signaling pathway. In particular, we investigate the E2-induced expression and cellular distribution of DPP III monozinc exopeptidase, a member of the Nrf-2/Keap-1 pathway, upon hyperoxia treatment. We find that DPP III accumulates in the nucleus in response to hyperoxia. Further, we show that combined induction of hyperoxia and E2 administration have an additive effect on the nuclear accu- mulation of DPP III. The level of nuclear accumulation of DPP III is comparable to nuclear accumulation of Nrf-2 in healthy female mice exposed to hyperoxia. In ovariectomized females exposed to hyperoxia, supplementation of E2 induced upregulation of DPP III, Ho-1, Sirt-1 and downregulation of Ppar-γ. While other cytoprotective mechanisms cannot be excluded, these findings demonstrate a prominent role of DPP III, along with Sirt-1, in the E2-mediated protection against hyperoxia.	SCI PUBLICATION
Synthesis of new 2-aminoimidazolones with antiproliferative activity via base promoted amino-b-lactam rearrangement Author or contact: Tonko Dražić, Katarina Vazdar, Mario Vazdar, Marijana Đaković, Ana-Matea Mikecin, Marijeta Kralj, Martina Malnar, Silva Hećimović, Ivan Habuš Journal: Tetrahedron Publisher: Elsevier Year: 2015 Description: A facile and efficient transformation of amino-b-lactam guanidines to 2-aminoimidazolones is described. The base-promoted transformation proceeds in two steps, with the rearrangement of four-membered b- lactam ring to five-membered imidazolone and subsequent E1cB elimination and formation of double bond at the 4-position of imidazolone ring, which is supported with quantum chemical calculations. The benzoylaminoimidazolone and 2-aminoimidazolone products are obtained in high yields. The benzoy- laminoimidazolone products show antiproliferative activity in HCT116 (colon carcinoma) and H460 (lung carcinoma) cell lines.	SCI PUBLICATION
Clusters of male and female Alzheimer’s disease patients in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database Author or contact: Dragan Gamberger, Bernard Ženko, Alexis Mitelpunkt, Netta Shachar, Nada Lavrač Publisher: Springer Year: 2016 Description: This paper presents homogeneous clusters of patients, identified in the Alzheimer’s Disease Neu- roimaging Initiative (ADNI) data population of 317 females and 342 males, described by a total of 243 bio- logical and clinical descriptors. Clustering was performed with a novel methodology, which supports identification of patient subpopulations that are homogeneous regarding both clinical and biological descriptors. Properties of the constructed clusters clearly demonstrate the differences between female and male Alzheimer’s disease patient groups. The major difference is the existence of two male subpopulations with unexpected values of intracerebral and whole brain volumes.	SCI PUBLICATION
The role of conserved Cys residues in Brassica rapa auxin amidohydrolase: Cys139 is crucial for the enzyme activity and Cys320 regulates enzyme stab... Author or contact: Ana Smolko, Filip Šupljika, Jelena Martinčić, Nina Jajčanin-Jozić, Marina Grabar-Branilović, Sanja Tomić, Jutta Ludwig-Muller, Ivo Piantanida, Branka Salopek-Sondi Journal: Phys. Chem. Chem. Phys. Publisher: The Royal Society of Chemistry Year: 2016 Description: Brassica rapa auxin amidohydrolase (BrILL2) participates in the homeostasis of the plant hormones auxins by hydrolyzing the amino acid conjugates of auxins, thereby releasing the free active form of hormones. Herein, the potential role of the two conserved Cys residues of BrILL2 (at sequence positions 139 and 320) has been investigated by using interdisciplinary approaches and methods of molecular biology, biochemistry, biophysics and molecular modelling. The obtained results show that both Cys residues participate in the regulation of enzyme activity. Cys320 located in the satellite domain of the enzyme is mainly responsible for protein stability and regulation of enzyme activity through polymer formation, as has been revealed by enzyme kinetics and differential scanning calorimetry analysis of the BrILL2 wild type and mutants C320S and C139S. Cys139 positioned in the active site of the catalytic domain is involved in the coordination of one Mn2+ ion of the bimetal center and is crucial for the enzymatic activity. Although the point mutation Cys139 to Ser causes the loss of enzyme activity, it does not affect the metal binding to the BrILL2 enzyme, as has been shown by isothermal titration calorimetry, circular dichroism spectropolarimetry and differential scanning calorimetry data. MD simulations (200 ns) revealed a different active site architecture of the BrILL2C139S mutant in comparison to the wild type enzyme. Additional possible reasons for the inactivity of the BrILL2C139S mutant have been discussed based on MD simulations and MM-PBSA free energy calculations of BrILL2 enzyme complexes (wt and C139S mutant) with IPA-Ala as a substrate.	SCI PUBLICATION
Offset-Sparsity Decomposition for Enhancement of Color Microscopic Image of Stained Specimen in Histopathology: Further Results Author or contact: Ivica Kopriva 1, Marijana Popović Hadžija 2, Mirko Hadžija 2 and Gorana Aralica 3,4 Year: 2015 Description: Recently, novel data-driven offset-sparsity decomposition (OSD) method was proposed by us to increase colorimetric difference between tissue-structures present in the color microscopic image of stained specimen in histopathology. The OSD method performs additive decomposition of vectorized spectral images into image-adapted offset term and sparse term. Thereby, the sparse term represents an enhanced image. The method was tested on images of the histological slides of human liver stained with hematoxylin and eosin, anti-CD34 monoclonal antibody and Sudan III. Herein, we present further results related to increase of colorimetric difference between tissue structures present in the images of human liver specimens with pancreatic carcinoma metastasis stained with Gomori, CK7, CDX2 and LCA, and with colon carcinoma metastasis stained with Gomori, CK20 and PAN CK. Obtained relative increase of colorimetric difference is in the range [19.36%, 103.94%]. Keywords: Histopatological image enhancement, colorimetric difference, offset-sparisty decomposition.	SCI PUBLICATION
Dicationic derivatives of dinaphtotetraaza[14]annulene: Synthesis, crystal structures and the preliminary evaluation of their DNA binding properties Author or contact: Alicja Kazmierska, Marlena Gryl, Katarzyna Stadnicka, Leslaw Sieron, Andrzej Eilmes, Justyna Nowak, Marija Matković, Marijana Radić-Stojković, Ivo Piantanida, Julita Eilmes Journal: Tetrahedron Publisher: Elsevier Year: 2015 Description: Four new water-soluble, fluorescent derivatives of dinaphthotetraaza[14]annulene (DNTAA) have been synthesized varying in the structure, dimensions and spatial arrangements of their meso side groups. The products have been carefully characterized by elemental analyses, spectroscopy, crystal structures and quantum-chemical calculations employing DFT methodology. One representative product of the DNTAA series was tested for DNA binding using UV evis titrations, CD and thermal denaturation experiments. Intercalation of ds-DNA was recognized as a dominant binding mode. In contrast to non-fluorescent phenylene analogues (DBTAA), reported previously, DNTAA derivative showed threefold fluorescence increase upon DNA binding, and offered intriguing new applications as a fluorescent DNA/RNA dye.	SCI PUBLICATION
The 1,3-diaryltriazenido(p-cymene)ruthenium(II) complexes with a high in vitro anticancer activity Author or contact: Jure Vajs, Ivana Steiner, Anamaria Brozovic, Andrej Pevec, Andreja Ambriović-Ristov, Marija Matković, Ivo Piantanida, Damijana Urankar, Maja Osmak, Janez Košmrlj Journal: Journal of Inorganic Biochemistry Year: 2015	SCI PUBLICATION
Enhancement of antiproliferative activity by phototautomerization of anthrylphenols Author or contact: Marijeta Kralj, Lidija Uzelac, Yu-Hsuan Wang, Peter Wan, Martina Tireli, Kata Mlinarić-Majerski, Ivo Piantanida and Nikola Basarić Journal: Photochem. Photobiol. Sci. Publisher: The Royal Society of Chemistry Year: 2015 Description: Antiproliferative investigation has been conducted on 3 human cancer cell lines HCT 116 (colon), MCF-7 (breast), and H 460 (lung), on a series of 4 anthrylphenols in dark, and upon exposure to light (350 nm). 9-(2-Hydroxyphenyl)anthracene (1) moderately inhibits the proliferation, but the irradiation considerably enhances the effect. The other investigated anthracenes 4-6 exhibit antiproliferative activity in dark, which was not enhanced upon irradiation. The enhancement of the antiproliferative effect on irradiation of 1 was rationalized as being due to the formation of quinone methide (QM 2) by excited state proton transfer. QM 2 acts as an electrophilic species capable of reacting with biological molecules. Although QM 2 reacts with nucleotides, adducts could not be isolated. On the contrary, cysteine adduct 8 has been isolated and characterized, whereas adducts with glycine, serine and tripeptide glutathione have been characterized by MS. Non-covalent binding of 1 to DNA and bovine serum albumin was demonstrated by UV-vis, fluorescence and CD spectroscopy. However, straightforward conclusion about the DNA or ptotein alkylating (damaging) ability of 2 could not be drawn. The results obtained by the irradiations of 1 in the presence of DNA, amino acids and peptides, the cell cycle perturbation analysis, and in vitro translation of GFP suggest that the effect is not only due to the damage of DNA but also the impact on the cellular proteins. Considering that up to date all QM agents were assumed to target dominantly DNA, this is an important finding with impact to the further development of anticancer agents based on QMs.	SCI PUBLICATION
Sensing of Double-Stranded DNA/RNA Secondary Structures by Water Soluble Homochiral Perylene Bisimide Dyes Author or contact: Jana Gershberg, Marijana Radić Stojković, Marko Škugor, Sanja Tomić, Thomas H. Rehm, Stefanie Rehm, Chantu R. Saha-Mçller, Ivo Piantanida, and Frank Würthner Author's homepage: http://www.irb.hr/Ljudi/Ivo-Piantanida Journal: Chemistry, An European Journal Publisher: Whiley Year: 2015 Description: A broad series of homochiral perylene bisimide (PBI) dyes were synthesized that are appended with amino acids and cationic side chains at the imide positions. Self-assembly behavior of these ionic PBIs has been studied in aqueous media by UV/Vis spectroscopy, revealing formation of excitonically coupled H-type aggregates. The interactions of these ionic PBIs with different ds-DNA and ds-RNA have been explored by thermal denaturation, fluorimetric titration and circular dichroism (CD) experiments. These PBIs strongly stabilized ds-DNA/RNA against thermal denaturation as revealed by high melting temperatures of the formed PBI/polynucleotide complexes. Fluorimetric titrations showed that these PBIs bind to ds-DNA/RNA with high binding constants depending on the number of the positive charges in the side chains. Thus, spermine-containing PBIs with six positive charges each showed higher binding constants (log Ks = 9.2 – 9.8) than their dioxa analogues (log Ks = 6.5 – 7.9) having two positive charges each. Induced circular dichroism (ICD) of PBI assemblies created within DNA/RNA grooves was observed. These ICD profiles are strongly dependent on the steric demand of the chiral substituents of the amino acid units and the secondary structure of the DNA or RNA. The observed ICD effects can be explained by non-covalent binding of excitonically coupled PBI dimer aggregates into the minor groove of DNA and major groove of RNA which is further supported by molecular modeling studies.	SCI PUBLICATION
Molecular recognition of AT-DNA sequences by the induced CD pattern of dibenzotetraaza[14]annulene (DBTAA)–adenine derivatives Author or contact: Marijana Radić Stojković, Marko Škugor, Łukasz Dudek, Jarosław Grolik, Julita Eilmes and Ivo Piantanida Author's homepage: Ivo Piantanida Journal: Beilstein Journal of Organic Chemistry Publisher: Beilstein Institut Year: 2015 Description: An investigation of interactions of two novel and several known DBTAA-adenine conjugates with double stranded DNA and RNA has revealed the DNA/RNA groove as the dominant binding site, at variance to the majority of previously studied DBTAA analogues (DNA/RNA intercalators). Only DBTAA-propyl-adenine conjugates revealed molecular recognition of AT-DNA by an ICD band pattern > 300 nm, whereas significant ICD bands did not appear for other ds-DNA/RNA. A structure – activity relation for the studied series of compounds revealed that the essential structural features for the ICD recognition were: a) the presence of DNA-binding appendages (adenine side-chain and positively charged side-chain) on both DBTAA side-chains, and b) the presence of a short propyl linker, which does not support intramolecular aromatic stacking between DBTAA and adenine. The observed AT-DNA-ICD pattern differs from previously reported ss-DNA (poly dT) ICD recognition by strong negative ICD band at 350 nm, thus allowing dynamic differentiation between ss-DNA (poly dT) and coupled ds-AT-DNA	SCI PUBLICATION
Genome-wide analysis of tandem repeats in Tribolium castaneum genome reveals abundant and highly dynamic tandem repeat families with satellite DNA f... Author or contact: Martina Pavlek, Yevgeniy Gelfand, Miroslav Plohl, and Nevenka Meštrović Journal: DNA Research Publisher: Oxford Journals Year: 2015 Description: Although satellite DNAs arewell-explored components of heterochromatin and centromeres, little is known about emergence, dispersal and possible impact of comparably structured tandem repeats (TRs) on the genome-wide scale. Our bioinformatics analysis of assembled Tribolium castaneum genome disclosed significant contribution of TRs in euchromatic chromosomal arms and clear predominance of satellite DNA-typical 170 bp monomers in arrays of ≥5 repeats. By applying different experimental approaches, we revealed that the nine most prominent TR families Cast1–Cast9 extracted from the assembly comprise ∼4.3% of the entire genome and reside almost exclusively in euchromatic regions. Among them, seven families that build ∼3.9% of the genome are based on ∼170 and ∼340 bp long monomers. Results of phylogenetic analyses of 2500 monomers originating from these families show high-sequence dynamics, evident by extensive exchanges between arrays on non-homologous chromosomes. In addition, our analysis shows that concerted evolution acts more efficiently on longer than on shorter arrays. Efficient genome-wide distribution of nine TR families implies the role of transposition only in expansion of the most dispersed family, and involvement of other mechanisms is anticipated. Despite similarities in sequence features, FISH experiments indicate high-level compartmentalization of centromeric and euchromatic tandem repeats.	SCI PUBLICATION
A Steerable Filter Bank Approach to Endmembers Estimation in Imaging Spectroscopy Author or contact: Ivica Kopriva, Danielle Nuzillard Author's homepage: Ivica Kopriva Journal: 2015 IEEE International Geoscience and Remote Sensing Symposium Year: 2015 Description: Estimation of pure spectral signatures, called endmembers, is a key step in hyperspectral image (HI) analysis. We propose endmembers estimation method that uses Gabor Filter Banks (GFBs) to filter HI into set of HIs with different resolutions and orientations. Afterwards, set of approximate pure pixels is identified from each filtered HI by means of directivity based criterion. Hierarchical clustering is used to estimate candidate endmembers from sets of approximate pure pixels. Final estimate of endmembers is obtained after annotation of candidate endmembers with library of pure spectral signatures. Thereby, candidate with the smallest angular deviation with respect to corresponding pure spectra is selected as endmember estimate. Proposed method is compared favorably with five endmembers estimation methods using well-understood experimental AVIRIS Cuprite Nevada dataset.	SCI PUBLICATION
Methylated Host Cell Gene Promoters and Human Papillomavirus Type 16 and 18 Predicting Cervical Lesions and Cancer Author or contact: Nina Milutin Gašperov, Ivan Sabol, Pavao Planinić, Goran Grubišić, Ivan Fistonić, Ante Ćorušić, Magdalena Grce Author's homepage: http://www.irb.hr/Ljudi/Magdalena-Grce Journal: PLoS ONE Year: 2015 Description: Change in the host and/or human papillomavirus (HPV) DNA methylation profile is probably one of the main factors responsible for the malignant progression of cervical lesions to can- cer. To investigate those changes we studied 173 cervical samples with different grades of cervical lesion, from normal to cervical cancer. The methylation status of nine cellular gene promoters, CCNA1, CDH1, C13ORF18, DAPK1, HIC1, RARβ2, hTERT1, hTERT2 and TWIST1, was investigated by Methylation Specific Polymerase Chain Reaction (MSP). The methylation of HPV18 L1-gene was also investigated by MSP, while the methylated cyto- sines within four regions, L1, 5’LCR, enhancer, and promoter of the HPV16 genome cover- ing 19 CpG sites were evaluated by bisulfite sequencing. Statistically significant methylation biomarkers distinguishing between cervical precursor lesions from normal cer- vix were primarily C13ORF18and secondly CCNA1, and those distinguishing cervical can- cer from normal or cervical precursor lesions were CCNA1, C13ORF18, hTERT1, hTERT2 and TWIST1. In addition, the methylation analysis of individual CpG sites of the HPV16 ge- nome in different sample groups, notably the 7455 and 7694 sites, proved to be more impor- tant than the overall methylation frequency. The majority of HPV18 positive samples contained both methylated and unmethylated L1 gene, and samples with L1-gene methylat- ed forms alone had better prognosis when correlated with the host cell gene promoters’ methylation profiles. In conclusion, both cellular and viral methylation biomarkers should be used for monitoring cervical lesion progression to prevent invasive cervical cancer.	SCI PUBLICATION
Nonlinear Sparse Component Analysis with a Reference: Variable Selection in Genomics and Proteomics Author or contact: Ivica Kopriva, Sanja Kapitanović, and Tamara Čačev Author's homepage: Ivica Kopriva Journal: 12th International Conference on Latent Variable Analysis and Signal Separation Year: 2015 Description: Many scenarios occurring in genomics and proteomics involve small number of labeled data and large number of variables. To create prediction models robust to overfitting variable selection is necessary. We propose variable selection method using nonlinear sparse component analysis with a reference representing either negative (healthy) or positive (cancer) class. Thereby, component comprised of cancer related variables is automatically inferred from the geometry of nonlinear mixture model with a reference. Proposed method is compared with 3 supervised and 2 unsupervised variable selection methods on two-class problems using 2 genomic and 2 proteomic datasets. Obtained results, which include analysis of biological relevance of selected genes, are comparable with those achieved by supervised methods. Thus, proposed method can possibly perform better on unseen data of the same cancer type.	SCI PUBLICATION
A short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced a new set of spectroscopic responses to the ds-DNA secondary structure Author or contact: Marijana Radić Stojković, Patryciusz Piotrowski, Carsten Schmuck and Ivo Piantanida Author's homepage: Marijana Radić Stojković Journal: Organic & Biomolecular Chemistry Year: 2015 Description: A novel pyrene-guanidiniocarbonyl-pyrrole dye, characterised by a short, rigid linker between the two chromophores, interacts strongly with ds-DNA but only negligibly with ds-RNA. At neutral conditions the dye shows strong selectivity toward AT-DNA (in respect to GC-DNA). Binding is accompanied by a specific ICD band at 350 nm and fluorescence quenching for all DNA/RNA studied. At pH 5 the affinity of the dye is reversed, now favouring GC-DNA over AT-DNA. A strong emission increase for AT-DNA is observed but quenching for GC-DNA.	SCI PUBLICATION
Combination of Cyclopamine and Tamoxifen Promotes Survival and Migration of MCF-7 Breast Cancer Cells – Interaction of Hedgehog-Gli and Estrogen R... Author or contact: Maja Sabol, Diana Trnski, Zvonimir Uzarevic, Petar Ozretic, Vesna Musani, Maja Rafaj, Mario Cindric, Sonja Levanat Author's homepage: Maja Sabol Journal: PLOS ONE Year: 2014 Description: PTCH1 ; Gli1 ; sonic hedgehog ; estrogen receptor ; Breast Cancer	SCI PUBLICATION
Nme family of proteins—clues from simple animals Author or contact: Helena Ćetković, Dragutin Perina, Matija Harcet, Andreja Mikoč and Maja Herak Bosnar Author's homepage: Helena Ćetković Journal: Naunyn-Schmiedeberg's Arch Pharmacol Publisher: Springer Year: 2014 Description: Non-bilaterian metazoans, Porifera, NDPK, Nm23, Nme.	SCI PUBLICATION
A simple optical configuration for cell tracking by dark-field microscopy Author or contact: Vlatka Antolović, Maja Marinović, Vedrana Filić, Igor Weber Author's homepage: Igor Weber Journal: Journal of Microbiological Methods Publisher: Elsevier Year: 2014 Description: http://www.sciencedirect.com/science/article/pii/S0167701214001614 Dark-field microscopy, Annular aperture, Long-working-distance condenser, Cell migration, Tracking, Dictyostelium discoideum.	SCI PUBLICATION
The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases Author or contact: Vedrana Filić, Maja Marinović, Jan Faix, Igor Weber Author's homepage: Igor Weber Journal: Cellular and Molecular Life Sciences Publisher: Springer Year: 2014 Description: http://link.springer.com/article/10.1007%2Fs00018-014-1606-3 Rac, Scaffold proteins, Cell polarization, Cell migration, Rho GTPases, Dictyostelium.	SCI PUBLICATION
Centromere identity from the DNA point of view Author or contact: Miroslav Plohl, Nevenka Meštrović, Brankica Mravinac Author's homepage: Miroslav Plohl Journal: Chromosoma Publisher: Springer Year: 2014 Description: Centromere, Satellite DNA, Transposable elements, Transcription.	SCI PUBLICATION
Reconstruction of Sparse Signals from Highly Corrupted Measurements by Nonconvex Minimization Author or contact: Marko Filipović Journal: 2014 IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP) Year: 2014 Description: Compressive sensing, Sparse signal reconstruction, Nonconvex optimization, Restricted Isometry.	SCI PUBLICATION
Error Analysis of Low-rank Three-way Tensor Factorization Approach to Blind Source Separation Author or contact: Ivica Kopriva, Jean-Philip Royer, Nadège Thirion-Moreau, Pierre Comon Author's homepage: Ivica Kopriva Journal: 2014 IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP) Year: 2014 Description: Tensor models, multidimensional signal, blind source separation.	SCI PUBLICATION
Increased Adenovirus Type 5 Mediated Transgene Expression Due to RhoB Down-Regulation Author or contact: Dragomira Majhen, Nikolina Stojanović, Dunja Vukić, Chantal Pichon, Chloé Leduc, Maja Osmak, Andreja Ambriović-Ristov Author's homepage: Dragomira Majhen Journal: PLOS ONE Year: 2013 Description: This is the first study showing changed Ad5 trafficking pattern between cells expressing different amount of RhoB, indicating the role of RhoB in Ad5 intracellular trafficking.	SCI PUBLICATION

Publications

Browse InnoMol publications here

Bis-phenanthridinium–adenine conjugates as fluorescent and CD reporters for fine structural differences in ds-DNA/RNA and ss-RNA structures

Death by UVC Light Correlates with Protein Damage in Isogenic Human Tumor Cells: Primary Tumor SW480 versus its Metastasis SW620

Functional and Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula

Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo

Synthesis of new 2-aminoimidazolones with antiproliferative activity via base promoted amino-b-lactam rearrangement

Clusters of male and female Alzheimer’s disease patients in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database

The role of conserved Cys residues in Brassica rapa auxin amidohydrolase: Cys139 is crucial for the enzyme activity and Cys320 regulates enzyme stab...

Offset-Sparsity Decomposition for Enhancement of Color Microscopic Image of Stained Specimen in Histopathology: Further Results

Dicationic derivatives of dinaphtotetraaza[14]annulene: Synthesis, crystal structures and the preliminary evaluation of their DNA binding properties

The 1,3-diaryltriazenido(p-cymene)ruthenium(II) complexes with a high in vitro anticancer activity

Enhancement of antiproliferative activity by phototautomerization of anthrylphenols

Sensing of Double-Stranded DNA/RNA Secondary Structures by Water Soluble Homochiral Perylene Bisimide Dyes

Molecular recognition of AT-DNA sequences by the induced CD pattern of dibenzotetraaza[14]annulene (DBTAA)–adenine derivatives

Genome-wide analysis of tandem repeats in Tribolium castaneum genome reveals abundant and highly dynamic tandem repeat families with satellite DNA f...

A Steerable Filter Bank Approach to Endmembers Estimation in Imaging Spectroscopy

Methylated Host Cell Gene Promoters and Human Papillomavirus Type 16 and 18 Predicting Cervical Lesions and Cancer

Nonlinear Sparse Component Analysis with a Reference: Variable Selection in Genomics and Proteomics

A short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced a new set of spectroscopic responses to the ds-DNA secondary structure

Combination of Cyclopamine and Tamoxifen Promotes Survival and Migration of MCF-7 Breast Cancer Cells – Interaction of Hedgehog-Gli and Estrogen R...

Nme family of proteins—clues from simple animals

A simple optical configuration for cell tracking by dark-field microscopy

The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases

Centromere identity from the DNA point of view

Reconstruction of Sparse Signals from Highly Corrupted Measurements by Nonconvex Minimization

Error Analysis of Low-rank Three-way Tensor Factorization Approach to Blind Source Separation

Increased Adenovirus Type 5 Mediated Transgene Expression Due to RhoB Down-Regulation