Differential scanning calorimeter (DSC)
Contact: Filip Šupljika, Ivo Crnolatac
The Nano differential scanning calorimeter (Nano DSC) is specifically designed to determine the thermal stability and heat capacity of proteins and other macro-molecules in dilute solution, with the versatility and precision to perform molecular stability screening, ligand binding and pressure perturbation measurements.
The Nano DSC is designed to measure the amount of heat absorbed or released by dilute in-solution bio-molecules as they are heated or cooled.
Macromolecules such as proteins respond to heating or cooling by unfolding at a characteristic temperature. The more intrinsically stable the biopolymer, the higher the midpoint temperature of the unfolding transition.
| Nano DSC Specifications: | |
| Short-term Noise: | 0.015 μWatts |
| Baseline Stability: | ±0.028 μWatts |
| Response Time: | 7 seconds |
| Operating Temperature: | -10 °C to 130 °C or 160 °C |
| Temperature Scan Rate: | 0.05 °C to 2°C/minute |
| Pressurization Perturbation: | Built-in up to 6 atmospheres |
| Cell Volume: | 0.30 ml |
| Cell Geometry: | Fixed capillary |
| Cell Composition: | Platinum |
| Heat Measurement Type: | Power Compensation |